Our Investigator-Sponsored Trials (IST) program provides support for external clinical research that advances medical and/or scientific knowledge about our products and clinical candidates to enhance patient care. Our current IST portfolio includes programs for brentuximab vedotin in lymphoma and tucatinib in breast and other HER2-expressing cancers. Other indications may be considered with strong scientific rationale.
The objective of our IST program is to provide funding and/or study drug for clinical research that will:
- Address unmet medical needs with new scientific data
- Support pilot studies that explore the feasibility of new treatments
For additional information regarding support for ISTs, please see our Program Overview. To discuss your proposed research or for questions about our process, please contact your regional Medical Science Liaison (MSL) or email us at IST@seagen.com for help identifying the MSL in your region.
Letters of Intent are accepted on an ongoing basis via our online portal.
The regional MSL will present the proposal to the Investigator-Sponsored Trial Review Committee (ISTRC). If accepted, a full protocol and budget is requested within 90 days, which will be reviewed by the ISTRC. Following ISTRC approval, regulatory and contracting activities may begin.
A list of review criteria, Sponsor-Investigator responsibilities, and Seattle Genetics responsibilities are provided in our Program Overview (PDF).