Extending the Impact of ADCs

Beyond broad internal development of our antibody-drug conjugate (ADC) technology, we have entered into collaborations with a number of industry-leading biotechnology and pharmaceutical companies. These licensing activities extend the reach of our technology as collaborators investigate numerous targets in many therapeutic areas. Across both internal and collaborator programs, there are more than 20 ADCs in clinical development using our technology.

In addition to extending the reach of our technology into additional programs, our ADC technology licensing agreements have generated more than $350 million to date. They also provide us with future pipeline opportunities through co-development or opt-in rights to new ADC product candidates.

We have two types of ongoing ADC collaborations:

Under our ADC license agreements with AbbVie, Astellas, Bayer, Celldex, Genentech, GlaxoSmithKline, Pfizer and Progenics, we are entitled to receive upfront payments, milestones and royalties on net sales of any resulting ADC products. We have the potential to receive several billion in future milestone payments from our current ADC collaborations. Our licensees are responsible for all development, manufacturing and commercialization activities under these collaborations.

Our ADC co-development agreements with Astellas and Genmab provide Seattle Genetics with opportunities to supplement our internal pipeline through opt-in rights to 50:50 co-development and profit-sharing for ADC product candidates. Under our Agensys deal, we are co-developing ASG-15ME and enfortumab vedotin (ASG-22ME). Through our Genmab deals, we have opt-in rights to the Tissue Factor (TF) ADC program at completion of phase 1 clinical trials.

ADC Collaborator Pipeline

Glembatumumab vedotin (anti-GPNMB ADC)

Breast cancer


Glembatumumab vedotin (anti-GPNMB ADC)

Melanoma


Anti-TIM1 ADC

Renal cell carcinoma


Polatuzumab vedotin (anti-CD79b ADC; RG7596)

Non-Hodgkin lymphoma


Anti-MUC16 ADC (RG7882)

Ovarian, pancreatic cancer


RG7986

Non-Hodgkin lymphoma


Anti-S. aureus TAC (RG7861)

Antibacterial


Undisclosed ADCs

Cancer

Preclinical

Depatuxizumab mafodotin

Glioblastoma


ABBV-221

Solid tumors


ABBV-399

Solid tumors


ABBV-838

Multiple myeloma


Undisclosed ADCs

Preclinical

Anti-PSMA ADC

Prostate cancer


AGS-16C3F

Renal cell carcinoma


AGS67E

Cancer


Anti-C4.4a ADC

Solid tumors


Anti-BCMA ADC

Multiple myeloma


Tisotumab vedotin (anti-TF ADC)

Solid tumors

Opt-in at end of phase 1

HuMax-AXL-ADC (anti-AXL ADC)

Solid tumors


Pfizer logo

Undisclosed ADC

Cancer

Preclinical