ADC Collaborations

There are more than 15 collaborator ADC programs in clinical development using our technology.

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ADC Technology

Our pipeline of empowered antibody-based product candidates is based primarily on our ADC technology.

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A diversified product pipeline

We are the industry leader in antibody-drug conjugates (ADCs), a technology designed to harness the targeting ability of monoclonal antibodies to deliver cell-killing agents directly to cancer cells. Our robust pipeline of empowered antibody-based therapies is designed to address significant unmet medical needs.

Program Therapeutic Area Preclinical Phase 1 Phase 2 Phase 3 Approved
ADCETRIS® (brentuximab vedotin)
Relapsed Hodgkin lymphoma (HL)
Relapsed systemic anaplastic large cell lymphoma
HL post-autologous transplantation consolidation
Brentuximab Vedotin
ALCANZA: CD30-expressing cutaneous T-cell lymphoma (top-line data reported)
ECHELON-1: Frontline HL
(chemotherapy +/− brentuximab vedotin) (enrollment complete)
ECHELON-2: Frontline CD30-expressing mature T-cell lymphoma
(chemotherapy +/− brentuximab vedotin)
Frontline DLBCL (rituximab + chemotherapy +/− brentuximab vedotin)
Relapsed CD30-expressing DLBCL (rituximab + bendamustine +/− brentuximab vedotin)
Frontline HL in patients 60+ (+/− chemotherapy)
Second-line HL
(+ nivolumab)
Relapsed NHL
(+ nivolumab)
Systemic lupus erythematosus
SGN-CD33A (vadastuximab talirine)
CASCADE: Frontline older acute myeloid leukemia (AML)
Frontline myelodysplastic syndrome (MDS) (+ HMA)
Relapsed AML pre/post allo-transplant
Frontline AML
(+ chemotherapy)
AML (monotherapy and
+ HMA)
SGN-CD19A (denintuzumab mafodotin)
Relapsed DLBCL (rituximab + chemotherapy +/− SGN-CD19A)
Frontline DLBCL
(+ chemotherapy) (planned)
Metastatic breast cancer
Metastatic urothelial cancer
ASG-22ME* (enfortumab vedotin)
Metastatic urothelial cancer
Metastatic renal cell carcinoma
Metastatic or unresectable solid tumors; hematologic malignancies
Relapsed NHL
Multiple myeloma (planned)

*Co-development program with Astellas
**Non-fucosylated antibody empowered with our SEA technology, resulting in a novel immuno-oncology agent

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