ADC Collaborations

There are 20 collaborator ADC programs in clinical development using our technology.

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ADC Technology

Our pipeline of empowered antibody-based product candidates is based primarily on our ADC technology.

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A diversified product pipeline

We are the industry leader in antibody-drug conjugates (ADCs), a technology designed to harness the targeting ability of monoclonal antibodies to deliver cell-killing agents directly to cancer cells. Our robust pipeline of empowered antibody-based therapies is designed to address significant unmet medical needs.

Program Therapeutic Area Preclinical Phase 1 Phase 2 Pivotal/ Phase 3 Approved
ADCETRIS® (brentuximab vedotin)
 
Relapsed Hodgkin lymphoma (HL)
         
 
 
Relapsed systemic anaplastic large cell lymphoma
         
 
 
HL post-autologous transplantation consolidation
         
Brentuximab Vedotin
 
ALCANZA: Relapsed CD30-expressing cutaneous T-cell lymphoma (enrollment complete)
         
 
 
ECHELON-1: Frontline HL
(chemotherapy +/− brentuximab vedotin) (target enrollment complete)
         
 
 
ECHELON-2: Frontline CD30-expressing mature T-cell lymphoma
(chemotherapy +/− brentuximab vedotin)
         
 
 
Frontline HL in patients 60+ (+/− chemotherapy)
         
 
 
Frontline DLBCL (rituximab + chemotherapy +/− brentuximab vedotin)
         
 
 
Relapsed CD30-expressing DLBCL (rituximab + bendamustine +/− brentuximab vedotin)
         
 
 
Second-line HL
(+ nivolumab)
         
 
 
Relapsed NHL
(+ nivolumab) (planned)
         
 
 
Systemic lupus erythematosus
         
SGN-CD33A (vadastuximab talirine)
 
Frontline older acute myeloid leukemia (AML) (planned)
         
 
 
Frontline myelodysplastic syndrome (MDS) (+ HMA)(planned)
         
 
 
Relapsed AML pre/post allo-transplant
         
 
 
Frontline AML
(+ chemotherapy)
         
 
 
AML (monotherapy and
+ HMA)
         
SGN-CD19A (denintuzumab mafodotin)
 
Relapsed DLBCL (rituximab + chemotherapy +/− SGN-CD19A)
         
 
 
Frontline DLBCL
(+ chemotherapy) (planned)
         
 
 
Relapsed acute lymphoblastic leukemia
         
SGN-LIV1A
 
Relapsed breast cancer
         
SGN-CD70A
 
Relapsed NHL, renal cell carcinoma
         
ASG-22ME* (enfortumab vedotin)
 
Relapsed solid tumors
         
ASG-15ME*
 
Relapsed bladder cancer
         
SEA-CD40**
 
Relapsed solid tumors
         
SGN-CD19B
 
NHL
         
SGN-CD123A
 
AML
         

*Co-development program with Agensys, an affiliate of Astellas
**Non-fucosylated antibody empowered with our SEA technology, resulting in a novel immuno-oncology agent

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