ADC Collaborations

There are nearly 20 collaborator ADC programs in clinical development using our technology.

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ADC Technology

Our pipeline of empowered antibody-based product candidates is based primarily on our ADC technology.

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A diversified product pipeline

We are the industry leader in antibody-drug conjugates (ADCs), a technology designed to harness the targeting ability of monoclonal antibodies to deliver cell-killing agents directly to cancer cells. Our robust pipeline of empowered antibody-based therapies is designed to address significant unmet medical needs.

Program Therapeutic Area Preclinical Phase 1 Phase 2 Pivotal/ Phase 3 Approved
ADCETRIS® (brentuximab vedotin)
Relapsed Hodgkin lymphoma (HL)
Relapsed systemic anaplastic large cell lymphoma
HL post-autologous transplantation consolidation
Brentuximab Vedotin
ALCANZA: Relapsed CD30-expressing cutaneous T-cell lymphoma (enrollment complete)
ECHELON-1: Frontline HL
(chemotherapy +/− brentuximab vedotin) (target enrollment complete)
ECHELON-2: Frontline CD30-expressing mature T-cell lymphoma
(chemotherapy +/− brentuximab vedotin)
Frontline HL in patients 60+ (+/− chemotherapy)
Frontline DLBCL (rituximab + chemotherapy +/− brentuximab vedotin)
Relapsed CD30-expressing DLBCL (rituximab + bendamustine +/− brentuximab vedotin)
Systemic lupus erythematosus
Second-line HL
(+ nivolumab)
Relapsed NHL
(+ nivolumab) (planned)
SGN-CD33A (vadastuximab talirine)
Relapsed acute myeloid leukemia (AML)
Frontline AML
(+ hypomethylating agents (HMA))
Frontline AML
(+ chemotherapy)
Pre/post allo-transplant relapsed AML
Frontline myelodysplastic syndrome (+ HMA) (planned)
SGN-CD19A (denintuzumab mafodotin)
Relapsed DLBCL (rituximab + chemotherapy +/− SGN-CD19A)
Frontline DLBCL
(+ chemotherapy) (planned)
Relapsed acute lymphoblastic leukemia, aggressive lymphomas
Relapsed NHL
Relapsed breast cancer
Relapsed NHL, renal cell carcinoma
ASG-22ME* (enfortumab vedotin)
Relapsed solid tumors
Relapsed bladder cancer
Relapsed solid tumors

*Co-development program with Agensys, an affiliate of Astellas
**Non-fucosylated antibody empowered with our SEA technology, resulting in a novel immuno-oncology agent

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