ADC Collaborations

There are more than 15 collaborator ADC programs in clinical development using our technology.

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ADC Technology

Our pipeline of empowered antibody-based product candidates is based primarily on our ADC technology.

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A diversified product pipeline

We are the industry leader in antibody-drug conjugates (ADCs), a technology designed to harness the targeting ability of monoclonal antibodies to deliver cell-killing agents directly to cancer cells. Our robust pipeline of empowered antibody-based therapies is designed to address significant unmet medical needs.

Program Therapeutic Area Preclinical Phase 1 Phase 2 Pivotal/ Phase 3 Approved
ADCETRIS® (brentuximab vedotin)
 
Relapsed Hodgkin lymphoma (HL)
         
 
 
Relapsed systemic anaplastic large cell lymphoma
         
Brentuximab Vedotin
 
AETHERA: Post-transplant HL relapse prevention
         
 
 
ALCANZA: CD30+ cutaneous T-cell lymphoma
         
 
 
ECHELON-1: Frontline HL
(+ chemotherapy)
         
 
 
ECHELON-2: Frontline CD30+ mature T-cell lymphomas (+ chemo)
         
 
 
Frontline HL in patients 60+ (+/− other agents)
         
 
 
Frontline CD30+ DLBCL
(+ RCHP)
         
 
 
CD30+ non-lymphoma malignancies
         
 
 
CD30+ DLBCL (Rituxan + bendamustine +/− BV) (Planned)
         
 
 
Second-line HL
(+ bendamustine)
         
SGN-CD19A
 
DLBCL (R-ICE +/− SGN-CD19A) (Planned)
         
 
 
ALL, NHL
         
SGN-CD33A
 
AML (single agent and combinations)
         
SGN-LIV1A
 
Breast cancer
         
SGN-CD70A
 
NHL, renal cell carcinoma
         
ASG-22ME*
 
Solid tumors
         
ASG-15ME*
 
Bladder cancer
         
SEA-CD40**
 
Solid tumors
         

*Co-development program with Agensys, an affiliate of Astellas
**Non-fucosylated antibody utlizing a novel immuno-oncology technology

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