Advancing Breakthrough Therapies for Cancer

Seattle Genetics is a biotechnology company focused on developing and commercializing innovative, empowered antibody-based therapies for the treatment of cancer. We are the industry leader in antibody-drug conjugates (ADCs), a technology designed to harness the targeting ability of monoclonal antibodies to deliver cell-killing agents directly to cancer cells. ADCs are intended to spare non-targeted cells and thus reduce many of the toxic effects of traditional chemotherapy, while potentially enhancing antitumor activity.

First in a New Class of ADCs

The company’s first ADC product ADCETRIS® (brentuximab vedotin) is commercially available for two indications in more than 40 countries, including the U.S., Canada, Japan and members of the European Union. The approval of ADCETRIS makes it the first in a new class of ADCs.

To expand on the ADCETRIS opportunity, we are conducting a broad clinical development program to evaluate its therapeutic potential in earlier lines of its approved indications as well as in a range of other lymphoma and non-lymphoma settings.

Seattle Genetics is jointly developing ADCETRIS in collaboration with Takeda Pharmaceutical Company. Under the collaboration, Seattle Genetics has full commercialization rights to ADCETRIS in the United States and Canada. Takeda has exclusive rights to commercialize the product candidate in all other countries.

Advancing Our Robust ADC Pipeline

In addition to ADCETRIS, we are advancing a robust ADC product pipeline designed to address the unmet medical needs of people with cancer. Our strong research and development capabilities are our engine for innovation and
long-term growth. Seattle Genetics’ ADC technology is also employed by collaborators and, across both internal and collaborator programs, there are more than 20 ADCs in clinical development using our proprietary approach to empowering antibodies.

Seattle Genetics was founded in 1998 and is headquartered in Bothell, Washington, a suburb of Seattle. The company completed an initial public offering in March 2001, and is traded on the Nasdaq Stock Market under the symbol SGEN. We have more than 600 employees throughout the United States, all with a passion for helping people living with cancer.

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